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SDC-1 binds to HS and CS, while GPC-1 contains only an HS chain and lacks CS [26]

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Semaglutide and Tirzepatide are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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For people with prediabetes or insulin resistance who do not yet meet diagnostic criteria for type 2 diabetes, tirzepatide can normalize glucose metabolism before the disease progresses

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